Risperidone and Bupropion Interaction
Drug interaction information between Risperidone and Bupropion.
Risperidone and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Risperidone and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion blocks the liver from processing risperidone, which can lead to higher levels of this medicine in your body.
FDA Label Information
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Erythromycin major
- Ranitidine major
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Risperidone + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Risperidone's 20. In the minor band specifically: Risperidone has 9 (also Fluoxetine, Clozapine, Dopamine, Carbidopa/Levodopa); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Risperidone and Bupropion?
Bupropion blocks the liver from processing risperidone, which can lead to higher levels of this medicine in your body.
Risperidone carries more major-labeled pairs than Bupropion
SPL source-record counts only. This page's band is minor · classes on file: Risperidone (Atypical Antipsychotic); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Risperidone has 6 major-labeled pairs vs Bupropion's 1. This page itself is in the minor band, not the major band.
6 major · 5 moderate · 9 minor · 20 total
- Other minor peers for Risperidone
- Fluoxetine
- Clozapine
- Dopamine
- Carbidopa/Levodopa
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.