Risperidone and Lithium Interaction
Drug interaction information between Risperidone and Lithium.
Risperidone and Lithium have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Risperidone and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking risperidone does not change the amount of lithium that stays in your bloodstream or how your body handles it.
FDA Label Information
Do not exceed twice the patient’s usual dose Enzyme (CYP3A) inhibitors Ranitidine 150 mg twice daily 1 mg single dose 1.2 1.4 Dose adjustment not needed Cimetidine 400 mg twice daily 1 mg single dose 1.1 1.3 Dose adjustment not needed Erythromycin 500 mg four times daily 1 mg single dose 1.1 0.94 Dose adjustment not needed Other Drugs Amitriptyline 50 mg twice daily 3 mg twice daily 1.2 1.1 Dose adjustment not Needed *Change relative to reference Effect of Risperidone on other drugs Lithium Repeated oral doses of risperidone tablets (3 mg twice daily) did not affect the exposure (AUC) or...
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Erythromycin major
- Ranitidine major
- Cimetidine major
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
- Azilsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Risperidone + Lithium?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Risperidone's 20. In the major band specifically: Risperidone has 6 (also Amitriptyline, Carbamazepine, Erythromycin, Ranitidine); Lithium has 2 (also Amlodipine/Benazepril).
What mechanism field is on file for Risperidone and Lithium?
Taking risperidone does not change the amount of lithium that stays in your bloodstream or how your body handles it.
Risperidone carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is major · classes on file: Risperidone (Atypical Antipsychotic); Lithium (Mood Stabilizer).
Risperidone has 6 major-labeled pairs vs Lithium's 2.
6 major · 5 moderate · 9 minor · 20 total
- Other major peers for Risperidone
- Amitriptyline
- Carbamazepine
- Erythromycin
- Ranitidine
2 major · 23 moderate · 65 minor · 90 total
- Other major peers for Lithium
- Amlodipine/Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.