Risperidone and Clozapine Interaction
Drug interaction information between Risperidone and Clozapine.
Risperidone and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Risperidone and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clozapine slows down how fast your body removes risperidone. This can cause risperidone to build up in your system.
FDA Label Information
Clozapine Chronic administration of clozapine with risperidone tablets may decrease the clearance of risperidone.
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Erythromycin major
- Ranitidine major
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Risperidone + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Risperidone's 20. In the minor band specifically: Risperidone has 9 (also Fluoxetine, Dopamine, Bupropion, Carbidopa/Levodopa); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Risperidone and Clozapine?
Clozapine slows down how fast your body removes risperidone. This can cause risperidone to build up in your system.
Risperidone carries more major-labeled pairs than Clozapine
SPL source-record counts only. This page's band is minor · classes on file: Risperidone (Atypical Antipsychotic); Clozapine (Atypical Antipsychotic).
Risperidone has 6 major-labeled pairs vs Clozapine's 0. This page itself is in the minor band, not the major band.
6 major · 5 moderate · 9 minor · 20 total
- Other minor peers for Risperidone
- Fluoxetine
- Dopamine
- Bupropion
- Carbidopa/Levodopa
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.