Risperidone and Amitriptyline Interaction
Drug interaction information between Risperidone and Amitriptyline.
Risperidone and Amitriptyline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Risperidone and Amitriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amitriptyline causes a very small increase in risperidone levels in the body, but the change is not large enough to be significant.
FDA Label Information
Dose adjustment is not recommended for risperidone tablets when co-administered with ranitidine, cimetidine, amitriptyline, or erythromycin [see Table 18 ] . Do not exceed twice the patient’s usual dose Enzyme (CYP3A) inhibitors Ranitidine 150 mg twice daily 1 mg single dose 1.2 1.4 Dose adjustment not needed Cimetidine 400 mg twice daily 1 mg single dose 1.1 1.3 Dose adjustment not needed Erythromycin 500 mg four times daily 1 mg single dose 1.1 0.94 Dose adjustment not needed Other Drugs Amitriptyline 50 mg twice daily 3 mg twice daily 1.2 1.1 Dose adjustment not Needed *Change relative...
Risperidone Also Interacts With
- Carbamazepine major
- Lithium major
- Erythromycin major
- Ranitidine major
- Cimetidine major
Amitriptyline Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Disulfiram minor
- Flecainide minor
Frequently Asked Questions
What SPL severity band is on file for Risperidone + Amitriptyline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amitriptyline has 21 labeled pairs on file vs Risperidone's 20. In the major band specifically: Risperidone has 6 (also Carbamazepine, Lithium, Erythromycin, Ranitidine); Amitriptyline has 1.
What mechanism field is on file for Risperidone and Amitriptyline?
Amitriptyline causes a very small increase in risperidone levels in the body, but the change is not large enough to be significant.
Risperidone carries more major-labeled pairs than Amitriptyline
SPL source-record counts only. This page's band is major · classes on file: Risperidone (Atypical Antipsychotic); Amitriptyline (Tricyclic Antidepressant (TCA)).
Risperidone has 6 major-labeled pairs vs Amitriptyline's 1.
6 major · 5 moderate · 9 minor · 20 total
- Other major peers for Risperidone
- Carbamazepine
- Lithium
- Erythromycin
- Ranitidine
1 major · 0 moderate · 20 minor · 21 total
Amitriptyline has no other major-band peer in this dataset besides Risperidone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.