Tranylcypromine and Carbamazepine Interaction
Drug interaction information between Tranylcypromine and Carbamazepine.
Tranylcypromine and Carbamazepine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tranylcypromine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can cause a dangerous rise in blood pressure or a serious condition called serotonin syndrome. This happens because both medications change how your brain and body handle certain chemicals.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Tranylcypromine + Carbamazepine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Tranylcypromine's 42. In the moderate band specifically: Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Lithium, Chlorpromazine); Carbamazepine has 16 (also Lithium, Apixaban, Desmopressin, Dronedarone).
What mechanism field is on file for Tranylcypromine and Carbamazepine?
Taking these two drugs together can cause a dangerous rise in blood pressure or a serious condition called serotonin syndrome. This happens because both medications change how your brain and body handle certain chemicals.
Tranylcypromine carries more major-labeled pairs than Carbamazepine
SPL source-record counts only. This page's band is moderate · classes on file: Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)); Carbamazepine (Anticonvulsant).
Tranylcypromine has 7 major-labeled pairs vs Carbamazepine's 3. This page itself is in the moderate band, not the major band.
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Lithium
- Chlorpromazine
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Apixaban
- Desmopressin
- Dronedarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.