Tranylcypromine and Lithium Interaction
Drug interaction information between Tranylcypromine and Lithium.
Tranylcypromine and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tranylcypromine and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these medications increases the risk of a toxic buildup of brain chemicals or a sudden spike in blood pressure. Both drugs affect the nervous system in ways that can lead to these severe reactions.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Tranylcypromine + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Tranylcypromine's 42. In the moderate band specifically: Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Chlorpromazine); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Tranylcypromine and Lithium?
Combining these medications increases the risk of a toxic buildup of brain chemicals or a sudden spike in blood pressure. Both drugs affect the nervous system in ways that can lead to these severe reactions.
Tranylcypromine carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is moderate · classes on file: Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)); Lithium (Mood Stabilizer).
Tranylcypromine has 7 major-labeled pairs vs Lithium's 2. This page itself is in the moderate band, not the major band.
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Chlorpromazine
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.