Theophylline and Propranolol Interaction
Drug interaction information between Theophylline and Propranolol.
Theophylline and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Theophylline and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Propranolol can slow down how fast your body breaks down theophylline. This can cause the medicine to build up to unsafe levels in your blood.
FDA Label Information
Propranolol Similar to cimetidine and pharmacologic interaction.
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Theophylline + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Propranolol's 44. In the minor band specifically: Theophylline has 54 (also Methotrexate, Diazepam, Lithium, Erythromycin); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Theophylline and Propranolol?
Propranolol can slow down how fast your body breaks down theophylline. This can cause the medicine to build up to unsafe levels in your blood.
Theophylline carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Theophylline (Methylxanthine Bronchodilator); Propranolol (Non-Selective Beta-Blocker).
Theophylline has 27 major-labeled pairs vs Propranolol's 0. This page itself is in the minor band, not the major band.
27 major · 5 moderate · 54 minor · 86 total
- Other minor peers for Theophylline
- Methotrexate
- Diazepam
- Lithium
- Erythromycin
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.