probenecid vs theophylline
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of probenecid and theophylline. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid (a component of ORLYNVAH) were added to human plasma.
Benemid
Theo-24, Elixophyllin
No summary available.
Theophylline is a medicine that helps you breathe easier. It treats the symptoms of asthma and other lung problems.
Information not available.
Theophylline treats the symptoms of long-term asthma and other lung diseases. These include emphysema and chronic bronchitis, which make it hard to breathe. This medicine helps to open up your airways so you can breathe easier.
Information not available.
Theophylline is a bronchodilator. It works by relaxing the muscles in your airways. This allows more air to flow in and out of your lungs.
- • Diarrhea
- • Nausea
- • Yeast infection of the vagina
- • Headache
- • Vomiting
- • Nausea
- • Vomiting
- • Headache
- • Trouble sleeping (insomnia)
- Diarrhoea 76
- Dyspnoea 52
- Adenovirus Infection 47
- Asthenia 47
- Fatigue 46
- Dyspnoea 2,273
- Asthma 1,942
- Pneumonia 1,318
- Wheezing 1,306
- Vomiting 1,101
No specific warnings noted.
If your theophylline levels get too high in your blood, it can cause serious side effects. These include severe vomiting, irregular heartbeats, and seizures. These can be life-threatening.
No pregnancy information available.
It is not known if theophylline can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if theophylline passes into breast milk, so talk to your doctor if you are breastfeeding.
How to Read This probenecid vs theophylline Comparison
probenecid is classified in the Uricosuric Agent drug class, while theophylline sits within the Methylxanthine Bronchodilator class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, probenecid has 268 submissions while theophylline has 7,940. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to probenecid can interfere with certain lab tests, making it look like there is more theophylline in your blood than there actually is.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for probenecid or theophylline.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.