Theophylline and Omeprazole Interaction
Drug interaction information between Theophylline and Omeprazole.
Theophylline and Omeprazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Theophylline and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole does not change how fast your body breaks down and gets rid of theophylline.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Amoxicillin major
- Famotidine major
- Prednisone major
Omeprazole Also Interacts With
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Theophylline + Omeprazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Omeprazole's 27. In the major band specifically: Theophylline has 27 (also Metoprolol, Albuterol, Amoxicillin, Famotidine); Omeprazole has 1.
What mechanism field is on file for Theophylline and Omeprazole?
Omeprazole does not change how fast your body breaks down and gets rid of theophylline.
Theophylline carries more major-labeled pairs than Omeprazole
SPL source-record counts only. This page's band is major · classes on file: Theophylline (Methylxanthine Bronchodilator); Omeprazole (Proton Pump Inhibitor (PPI)).
Theophylline has 27 major-labeled pairs vs Omeprazole's 1.
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Metoprolol
- Albuterol
- Amoxicillin
- Famotidine
1 major · 4 moderate · 22 minor · 27 total
Omeprazole has no other major-band peer in this dataset besides Theophylline.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.