Theophylline and Methotrexate Interaction
Drug interaction information between Theophylline and Methotrexate.
Theophylline and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Theophylline and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Methotrexate slows down how quickly your body removes theophylline. This can lead to higher levels of theophylline building up in your blood.
FDA Label Information
Methotrexate (MTX) Decreases theophylline clearance.
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Theophylline + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Methotrexate's 38. In the minor band specifically: Theophylline has 54 (also Propranolol, Diazepam, Lithium, Erythromycin); Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Theophylline and Methotrexate?
Methotrexate slows down how quickly your body removes theophylline. This can lead to higher levels of theophylline building up in your blood.
Theophylline carries more major-labeled pairs than Methotrexate
SPL source-record counts only. This page's band is minor · classes on file: Theophylline (Methylxanthine Bronchodilator); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
Theophylline has 27 major-labeled pairs vs Methotrexate's 0. This page itself is in the minor band, not the major band.
27 major · 5 moderate · 54 minor · 86 total
- Other minor peers for Theophylline
- Propranolol
- Diazepam
- Lithium
- Erythromycin
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.