What the FDA labels say about taking them together
Lorazepam and pregabalin
Pregabalin's FDA label of April 15, 2025 names lorazepam in its drug interactions section; the lorazepam labels PlainMeds reads (3) do not name pregabalin.
Check it at the source: the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC); the pregabalin FDA label on DailyMed (effective April 15, 2025, Viatris Specialty LLC).
What does the lorazepam label say about pregabalin?
Lorazepam's label (effective July 9, 2025) and its 2 other brand-application labels do not name pregabalin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
What does the pregabalin label say about lorazepam?
Pregabalin label, drug interactionsPharmacodynamics Multiple oral doses of LYRICA were co-administered with oxycodone, lorazepam, or ethanol.
Lyrica Cr label (Viatris Specialty LLC, March 12, 2026), drug interactionsPharmacodynamics Although no pharmacokinetic interactions were seen with LYRICA and ethanol, lorazepam, or oxycodone, additive effects on cognitive and gross motor functioning were seen when LYRICA was co-administered with these drugs.
Source: FDA drug label (Lyrica Cr, NDA209501), Viatris Specialty LLC, effective March 12, 2026 (SPL set f280bbd8-2af2-444a-bd96-e409337ca6dd), via openFDA
Source: FDA drug label (Pregabalin, NDA022488), Mylan Pharmaceuticals Inc., effective April 12, 2025 (SPL set ebe34db4-816d-4f0a-adbb-826693662754), via openFDA
Source: FDA drug label (Lyrica), NDA021446 (Upjohn), as published by Viatris Specialty LLC, effective April 15, 2025 (SPL set d4734e7d-5079-455e-8ff5-8f4539c998a9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lorazepam | Pregabalin | |
|---|---|---|
| Labeled for | Anxiety | Nerve pain and fibromyalgia, Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0344 per tablet 0.5 mg tablet | $0.0571 per capsule 100 mg capsule |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once