Pregabalin and Lorazepam Interaction
Drug interaction information between Pregabalin and Lorazepam.
Pregabalin and Lorazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pregabalin and Lorazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can slow down brain activity, which can lead to increased sleepiness or dizziness when they are used together.
FDA Label Information
Pharmacodynamics Multiple oral doses of pregabalin were co-administered with oxycodone, lorazepam, or ethanol.
Pregabalin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Lamotrigine minor
- Topiramate minor
- Carbamazepine minor
- Phenytoin minor
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Theophylline minor
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Pregabalin + Lorazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pregabalin has 14 labeled pairs on file vs Lorazepam's 11. In the minor band specifically: Pregabalin has 13 (also Lamotrigine, Topiramate, Carbamazepine, Phenytoin); Lorazepam has 11 (also Valproate, Clozapine, Probenecid, Theophylline).
What mechanism field is on file for Pregabalin and Lorazepam?
Both drugs can slow down brain activity, which can lead to increased sleepiness or dizziness when they are used together.
Pregabalin's labeled portfolio outnumbers Lorazepam
SPL source-record counts only. This page's band is minor · classes on file: Pregabalin (Anticonvulsant / Nerve Pain Agent); Lorazepam (Benzodiazepine).
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Pregabalin
- Lamotrigine
- Topiramate
- Carbamazepine
- Phenytoin
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Lorazepam
- Valproate
- Clozapine
- Probenecid
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.