lorazepam vs pregabalin
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Side-by-side comparison of lorazepam and pregabalin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Pharmacodynamics Multiple oral doses of pregabalin were co-administered with oxycodone, lorazepam, or ethanol.
Ativan
Lyrica
Lorazepam is a medicine that can help with anxiety. It belongs to a class of drugs called benzodiazepines, which slow down activity in the brain.
Pregabalin (Lyrica) is a medicine that can help manage nerve pain, fibromyalgia, and partial-onset seizures. It works by calming overactive nerves in your body.
Lorazepam is used to manage anxiety disorders. It can also provide short-term relief from anxiety symptoms or anxiety linked to depression. However, it is not for the stress of everyday life. Talk to your doctor regularly to see if you still need this medicine.
This medicine is used to treat nerve pain caused by diabetes, shingles, or spinal cord injury. It can also help with fibromyalgia, a condition that causes widespread pain. Pregabalin can also be used with other medicines to treat partial-onset seizures in adults and children as young as 1 month old.
Lorazepam works by affecting certain chemicals in your brain. It enhances the effects of a natural brain chemical called GABA. This helps to calm your nerves and reduce anxiety.
Pregabalin works by binding to certain areas in your brain and spinal cord. This action helps to reduce the release of chemicals that send pain signals. By reducing these signals, pregabalin can help to lessen pain and control seizures.
- • Feeling sleepy or drowsy
- • Dizziness
- • Dizziness
- • Sleepiness
- • Dry mouth
- • Swelling
- • Blurred vision
- Fatigue 13,457
- Nausea 13,332
- Diarrhoea 10,350
- Dyspnoea 9,235
- Anxiety 8,840
- Pain 25,902
- Fatigue 15,112
- Dizziness 14,524
- Nausea 14,053
- Headache 12,683
Taking lorazepam with opioid medicines can cause very serious problems, including slowed or shallow breathing, coma, and death. Only take them together if there are no other options. Lorazepam can be habit-forming, leading to abuse, misuse, and addiction, which can result in overdose or death. Using lorazepam for a long time can cause you to become dependent on it. Stopping it suddenly can cause dangerous withdrawal symptoms. Your doctor will slowly lower your dose to prevent withdrawal.
Pregabalin can cause swelling of the throat, head, and neck, which can be life-threatening. Get emergency help right away if this happens. This medicine can also increase the risk of suicidal thoughts or behavior. Watch for any changes in your mood or behavior. Pregabalin may cause dizziness and sleepiness, so be careful driving or operating machinery. Do not stop taking pregabalin suddenly, as this can cause increased seizures or other side effects.
Lorazepam may harm an unborn baby. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding while taking this medicine. It can pass into breast milk and affect the baby.
Taking pregabalin during pregnancy may slightly increase the risk of birth defects. If you are pregnant or plan to become pregnant, talk to your doctor about the risks and benefits of taking this medicine. Breastfeeding while taking pregabalin is not recommended.
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How to Read This lorazepam vs pregabalin Comparison
lorazepam is classified in the Benzodiazepine drug class, while pregabalin sits within the Anticonvulsant / Nerve Pain Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, lorazepam has 55,214 submissions while pregabalin has 82,274. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs can slow down brain activity, which can lead to increased sleepiness or dizziness when they are used together.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for lorazepam or pregabalin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.