Pregabalin and Lamotrigine Interaction
Drug interaction information between Pregabalin and Lamotrigine.
Pregabalin and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pregabalin and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not change how the body processes or clears the other drug from your system.
FDA Label Information
Specifically, there are no pharmacokinetic interactions between pregabalin and the following antiepileptic drugs: carbamazepine, valproic acid, lamotrigine, phenytoin, phenobarbital, and topiramate.
Pregabalin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Topiramate minor
- Lorazepam minor
- Carbamazepine minor
- Phenytoin minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Pregabalin + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lamotrigine has 24 labeled pairs on file vs Pregabalin's 14. In the minor band specifically: Pregabalin has 13 (also Topiramate, Lorazepam, Carbamazepine, Phenytoin); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Pregabalin and Lamotrigine?
These drugs do not change how the body processes or clears the other drug from your system.
Lamotrigine's labeled portfolio outnumbers Pregabalin
SPL source-record counts only. This page's band is minor · classes on file: Pregabalin (Anticonvulsant / Nerve Pain Agent); Lamotrigine (Anticonvulsant).
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Pregabalin
- Topiramate
- Lorazepam
- Carbamazepine
- Phenytoin
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.