Pregabalin and Phenytoin Interaction
Drug interaction information between Pregabalin and Phenytoin.
Pregabalin and Phenytoin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pregabalin and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not interfere with each other's levels in the blood. They can be used together without one drug changing how the other works in the body.
FDA Label Information
Specifically, there are no pharmacokinetic interactions between pregabalin and the following antiepileptic drugs: carbamazepine, valproic acid, lamotrigine, phenytoin, phenobarbital, and topiramate.
Pregabalin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Lamotrigine minor
- Topiramate minor
- Lorazepam minor
- Carbamazepine minor
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Pregabalin + Phenytoin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Pregabalin's 14. In the minor band specifically: Pregabalin has 13 (also Lamotrigine, Topiramate, Lorazepam, Carbamazepine); Phenytoin has 120 (also Atorvastatin, Omeprazole, Simvastatin, Methylphenidate).
What mechanism field is on file for Pregabalin and Phenytoin?
These drugs do not interfere with each other's levels in the blood. They can be used together without one drug changing how the other works in the body.
Phenytoin carries more major-labeled pairs than Pregabalin
SPL source-record counts only. This page's band is minor · classes on file: Pregabalin (Anticonvulsant / Nerve Pain Agent); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Pregabalin's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Pregabalin
- Lamotrigine
- Topiramate
- Lorazepam
- Carbamazepine
4 major · 23 moderate · 120 minor · 147 total
- Other minor peers for Phenytoin
- Atorvastatin
- Omeprazole
- Simvastatin
- Methylphenidate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.