Pregabalin and Acetaminophen/Oxycodone Interaction
Drug interaction information between Pregabalin and Acetaminophen/Oxycodone.
Pregabalin and Acetaminophen/Oxycodone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pregabalin and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down the central nervous system. Using them together can cause extreme sleepiness and make it hard to breathe.
FDA Label Information
Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants such as benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.
Pregabalin Also Interacts With
- Lamotrigine minor
- Topiramate minor
- Lorazepam minor
- Carbamazepine minor
- Phenytoin minor
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Oxycodone minor
Frequently Asked Questions
What SPL severity band is on file for Pregabalin + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen/Oxycodone has 23 labeled pairs on file vs Pregabalin's 14. In the moderate band specifically: Pregabalin has 1; Acetaminophen/Oxycodone has 2 (also Gabapentin).
What mechanism field is on file for Pregabalin and Acetaminophen/Oxycodone?
Both drugs slow down the central nervous system. Using them together can cause extreme sleepiness and make it hard to breathe.
Acetaminophen/Oxycodone's labeled portfolio outnumbers Pregabalin
SPL source-record counts only. This page's band is moderate · classes on file: Pregabalin (Anticonvulsant / Nerve Pain Agent); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
0 major · 1 moderate · 13 minor · 14 total
Pregabalin has no other moderate-band peer in this dataset besides Acetaminophen/Oxycodone.
0 major · 2 moderate · 21 minor · 23 total
- Other moderate peers for Acetaminophen/Oxycodone
- Gabapentin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.