Pregabalin and Acetaminophen/Oxycodone Interaction
Drug interaction information between Pregabalin and Acetaminophen/Oxycodone.
Pregabalin and Acetaminophen/Oxycodone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pregabalin and Acetaminophen/Oxycodone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs slow down the central nervous system. Using them together can cause extreme sleepiness and make it hard to breathe.
What To Do
Your doctor should monitor you closely for signs of breathing problems or severe drowsiness. Avoid this combination unless your healthcare provider says it is necessary.
FDA Label Information
Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants such as benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.
Pregabalin Also Interacts With
- Lamotrigine minor
- Topiramate minor
- Lorazepam minor
- Carbamazepine minor
- Phenytoin minor
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Oxycodone minor
Frequently Asked Questions
Can I take Pregabalin and Acetaminophen/Oxycodone together?
This is a moderate interaction. Your doctor should monitor you closely for signs of breathing problems or severe drowsiness. Avoid this combination unless your healthcare provider says it is necessary.
How serious is the interaction between Pregabalin and Acetaminophen/Oxycodone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Pregabalin and Acetaminophen/Oxycodone interact?
Both drugs slow down the central nervous system. Using them together can cause extreme sleepiness and make it hard to breathe.
Understanding the Pregabalin and Acetaminophen/Oxycodone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Pregabalin belongs to the Anticonvulsant / Nerve Pain Agent class and Acetaminophen/Oxycodone belongs to the Opioid Analgesic Combination class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs slow down the central nervous system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Pregabalin has 14 total documented interactions on file in this dataset, and Acetaminophen/Oxycodone has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you closely for signs of breathing problems or severe drowsiness. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Pregabalin or Acetaminophen/Oxycodone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.