Pregabalin and Carbamazepine Interaction
Drug interaction information between Pregabalin and Carbamazepine.
Pregabalin and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pregabalin and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines do not change how the body processes or breaks down each other. There is no known chemical interaction between them.
FDA Label Information
Specifically, there are no pharmacokinetic interactions between pregabalin and the following antiepileptic drugs: carbamazepine, valproic acid, lamotrigine, phenytoin, phenobarbital, and topiramate.
Pregabalin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Lamotrigine minor
- Topiramate minor
- Lorazepam minor
- Phenytoin minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Pregabalin + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Pregabalin's 14. In the minor band specifically: Pregabalin has 13 (also Lamotrigine, Topiramate, Lorazepam, Phenytoin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Pregabalin and Carbamazepine?
These two medicines do not change how the body processes or breaks down each other. There is no known chemical interaction between them.
Carbamazepine carries more major-labeled pairs than Pregabalin
SPL source-record counts only. This page's band is minor · classes on file: Pregabalin (Anticonvulsant / Nerve Pain Agent); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Pregabalin's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Pregabalin
- Lamotrigine
- Topiramate
- Lorazepam
- Phenytoin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.