Prednisone and Darunavir Interaction
Drug interaction information between Prednisone and Darunavir.
Prednisone and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prednisone and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir can interfere with how the body handles many steroids, but prednisone is less affected by this process than other options.
FDA Label Information
Alternative corticosteroids including beclomethasone, prednisone and prednisolone (for which PK and/or PD are less affected by strong CYP3A inhibitors relative to other steroids) should be considered, particularly for long term use.
Prednisone Also Interacts With
- Theophylline major
- Abiraterone minor
- Dolutegravir minor
- Fluconazole minor
- Montelukast minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Prednisone + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Prednisone's 9. In the minor band specifically: Prednisone has 8 (also Abiraterone, Dolutegravir, Fluconazole, Montelukast); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Prednisone and Darunavir?
Darunavir can interfere with how the body handles many steroids, but prednisone is less affected by this process than other options.
Darunavir carries more major-labeled pairs than Prednisone
SPL source-record counts only. This page's band is minor · classes on file: Prednisone (Corticosteroid); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Prednisone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Prednisone
- Abiraterone
- Dolutegravir
- Fluconazole
- Montelukast
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.