Prednisone and Darunavir Interaction
Drug interaction information between Prednisone and Darunavir.
Prednisone and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prednisone and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir can interfere with how the body handles many steroids, but prednisone is less affected by this process than other options.
What To Do
Prednisone is a preferred choice if you need a steroid while taking darunavir, particularly for long-term use.
FDA Label Information
Alternative corticosteroids including beclomethasone, prednisone and prednisolone (for which PK and/or PD are less affected by strong CYP3A inhibitors relative to other steroids) should be considered, particularly for long term use.
Prednisone Also Interacts With
- Theophylline major
- Abiraterone minor
- Dolutegravir minor
- Fluconazole minor
- Montelukast minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Prednisone and Darunavir together?
This is a minor interaction. Prednisone is a preferred choice if you need a steroid while taking darunavir, particularly for long-term use.
How serious is the interaction between Prednisone and Darunavir?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Prednisone and Darunavir interact?
Darunavir can interfere with how the body handles many steroids, but prednisone is less affected by this process than other options.
Understanding the Prednisone and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Prednisone belongs to the Corticosteroid class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir can interfere with how the body handles many steroids, but prednisone is less affected by this process than other options. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Prednisone has 9 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Prednisone is a preferred choice if you need a steroid while taking darunavir, particularly for long-term use. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Prednisone or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.