Prednisone and Montelukast Interaction
Drug interaction information between Prednisone and Montelukast.
Prednisone and Montelukast have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prednisone and Montelukast. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines do not have a known interaction that changes how they work in your body.
FDA Label Information
DRUG INTERACTIONS No dose adjustment is needed when montelukast sodium is co-administered with theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, and Cytochrome P450 (CYP) enzyme inducers [see Clinical Pharmacology (12.3)] .
Prednisone Also Interacts With
- Theophylline major
- Abiraterone minor
- Darunavir minor
- Dolutegravir minor
- Fluconazole minor
Montelukast Also Interacts With
- Warfarin minor
- Prednisolone minor
- Itraconazole minor
- Digoxin minor
- Theophylline minor
Frequently Asked Questions
What SPL severity band is on file for Prednisone + Montelukast?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Prednisone has 9 labeled pairs on file vs Montelukast's 8. In the minor band specifically: Prednisone has 8 (also Abiraterone, Darunavir, Dolutegravir, Fluconazole); Montelukast has 8 (also Warfarin, Prednisolone, Itraconazole, Digoxin).
What mechanism field is on file for Prednisone and Montelukast?
These two medicines do not have a known interaction that changes how they work in your body.
Prednisone carries more major-labeled pairs than Montelukast
SPL source-record counts only. This page's band is minor · classes on file: Prednisone (Corticosteroid); Montelukast (Leukotriene Receptor Antagonist).
Prednisone has 1 major-labeled pair vs Montelukast's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Prednisone
- Abiraterone
- Darunavir
- Dolutegravir
- Fluconazole
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Montelukast
- Warfarin
- Prednisolone
- Itraconazole
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.