Prednisone and Dolutegravir Interaction

Drug interaction information between Prednisone and Dolutegravir.

Prednisone and Dolutegravir have a documented minor interaction in FDA labeling.

FDA drug labeling documents a minor-severity interaction between Prednisone and Dolutegravir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Prednisone

Corticosteroid

Drug B

Dolutegravir

Integrase Strand Transfer Inhibitor

How They Interact

Prednisone does not change how the body handles dolutegravir.

FDA Label Information

Darunavir/ritonavir, lopinavir/ritonavir, rilpivirine, tenofovir, boceprevir, prednisone, rifabutin, and omeprazole had no clinically significant effect on the pharmacokinetics of dolutegravir.

Frequently Asked Questions

What SPL severity band is on file for Prednisone + Dolutegravir?

Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Dolutegravir has 28 labeled pairs on file vs Prednisone's 9. In the minor band specifically: Prednisone has 8 (also Abiraterone, Darunavir, Fluconazole, Montelukast); Dolutegravir has 21 (also Omeprazole, Estradiol, Carbamazepine, Rifampin).

What mechanism field is on file for Prednisone and Dolutegravir?

Prednisone does not change how the body handles dolutegravir.

Dolutegravir's labeled portfolio outnumbers Prednisone

SPL source-record counts only. This page's band is minor · classes on file: Prednisone (Corticosteroid); Dolutegravir (Integrase Strand Transfer Inhibitor).

Prednisone

1 major · 0 moderate · 8 minor · 9 total

Dolutegravir

1 major · 6 moderate · 21 minor · 28 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.