Prednisone and Dolutegravir Interaction
Drug interaction information between Prednisone and Dolutegravir.
Prednisone and Dolutegravir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prednisone and Dolutegravir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Prednisone does not change how the body handles dolutegravir.
What To Do
No special changes are needed when taking these two drugs together.
FDA Label Information
Darunavir/ritonavir, lopinavir/ritonavir, rilpivirine, tenofovir, boceprevir, prednisone, rifabutin, and omeprazole had no clinically significant effect on the pharmacokinetics of dolutegravir.
Prednisone Also Interacts With
- Theophylline major
- Abiraterone minor
- Darunavir minor
- Fluconazole minor
- Montelukast minor
Dolutegravir Also Interacts With
- Dofetilide major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Frequently Asked Questions
Can I take Prednisone and Dolutegravir together?
This is a minor interaction. No special changes are needed when taking these two drugs together.
How serious is the interaction between Prednisone and Dolutegravir?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Prednisone and Dolutegravir interact?
Prednisone does not change how the body handles dolutegravir.
Understanding the Prednisone and Dolutegravir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Prednisone belongs to the Corticosteroid class and Dolutegravir belongs to the Integrase Strand Transfer Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Prednisone does not change how the body handles dolutegravir. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Prednisone has 9 total documented interactions on file in this dataset, and Dolutegravir has 28. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No special changes are needed when taking these two drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Prednisone or Dolutegravir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.