Prednisone and Fluconazole Interaction
Drug interaction information between Prednisone and Fluconazole.
Prednisone and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prednisone and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
When you stop taking fluconazole, your body starts breaking down prednisone much faster. This can cause your steroid levels to drop too low, which can be dangerous.
FDA Label Information
Prednisone : There was a case report that a liver-transplanted patient treated with prednisone developed acute adrenal cortex insufficiency when a 3 month therapy with fluconazole was discontinued. The discontinuation of fluconazole presumably caused an enhanced CYP3A4 activity which led to increased metabolism of prednisone. Patients on long-term treatment with fluconazole and prednisone should be carefully monitored for adrenal cortex insufficiency when fluconazole is discontinued.
Prednisone Also Interacts With
- Theophylline major
- Abiraterone minor
- Darunavir minor
- Dolutegravir minor
- Montelukast minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Prednisone + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Prednisone's 9. In the minor band specifically: Prednisone has 8 (also Abiraterone, Darunavir, Dolutegravir, Montelukast); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Prednisone and Fluconazole?
When you stop taking fluconazole, your body starts breaking down prednisone much faster. This can cause your steroid levels to drop too low, which can be dangerous.
Fluconazole carries more major-labeled pairs than Prednisone
SPL source-record counts only. This page's band is minor · classes on file: Prednisone (Corticosteroid); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Prednisone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Prednisone
- Abiraterone
- Darunavir
- Dolutegravir
- Montelukast
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.