Indomethacin and Cyclosporine Interaction
Drug interaction information between Indomethacin and Cyclosporine.
Indomethacin and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Indomethacin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Indomethacin can interfere with how your kidneys work, which makes the cyclosporine more likely to cause kidney damage.
FDA Label Information
Cyclosporine Clinical Impact: Concomitant use of indomethacin capsules and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention: During concomitant use of indomethacin capsules and cyclosporine, monitor patients for signs of worsening renal function.
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Indomethacin + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Indomethacin's 35. In the minor band specifically: Indomethacin has 30 (also Meloxicam, Aspirin, Diclofenac, Lithium); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Indomethacin and Cyclosporine?
Indomethacin can interfere with how your kidneys work, which makes the cyclosporine more likely to cause kidney damage.
Cyclosporine carries more major-labeled pairs than Indomethacin
SPL source-record counts only. This page's band is minor · classes on file: Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Indomethacin's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Diclofenac
- Lithium
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.