What the FDA labels say about taking them together
Cyclosporine and indomethacin
Cyclosporine's FDA label of August 10, 2026 names indomethacin in its drug interactions section, and indomethacin's label names cyclosporine too. The indomethacin label: “Concomitant use of INDOCIN and cyclosporine may increase cyclosporine’s nephrotoxicity.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the cyclosporine label say about indomethacin?
Cyclosporine label, drug interactionsNo clinically significant pharmacokinetic interactions occurred between cyclosporine and aspirin, ketoprofen, piroxicam, or indomethacin.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the indomethacin label say about cyclosporine?
Indomethacin label, drug interactionsClinical Impact: Concomitant use of indomethacin capsules and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention: During concomitant use of indomethacin capsules and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates
Indomethacin label (Chartwell RX, LLC, March 26, 2025), drug interactionsCyclosporine Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin.
Source: FDA drug label (Indomethacin, NDA018829), Chartwell RX, LLC, effective March 26, 2025 (SPL set 9607920c-4d25-40b9-957e-87e9ca5574e8), via openFDA
Source: FDA drug label (Indocin, NDA018332), Zyla Life Sciences US LLC, effective December 16, 2024 (SPL set 73878376-1d24-423b-9f37-3666e83c95da), via openFDA
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Indomethacin | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.210 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once