Indomethacin and Diclofenac Interaction
Drug interaction information between Indomethacin and Diclofenac.
Indomethacin and Diclofenac have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Indomethacin and Diclofenac. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These are both NSAID pain relievers that work the same way, and combining them increases the chance of stomach or kidney damage.
FDA Label Information
NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Celecoxib minor
- Digoxin minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Indomethacin + Diclofenac?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Indomethacin has 35 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Indomethacin has 30 (also Meloxicam, Aspirin, Cyclosporine, Lithium); Diclofenac has 9 (also Celecoxib, Digoxin, Fluconazole, Mefenamic Acid).
What mechanism field is on file for Indomethacin and Diclofenac?
These are both NSAID pain relievers that work the same way, and combining them increases the chance of stomach or kidney damage.
Indomethacin's labeled portfolio outnumbers Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Cyclosporine
- Lithium
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Celecoxib
- Digoxin
- Fluconazole
- Mefenamic Acid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.