Indomethacin and Perindopril Interaction
Drug interaction information between Indomethacin and Perindopril.
Indomethacin and Perindopril have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Indomethacin and Perindopril. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Using these medicines at the same time can cause your blood potassium levels to rise too high.
What To Do
Your doctor may need to adjust your doses and will likely order regular blood tests to check your potassium.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Warfarin moderate
- Meloxicam minor
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Cyclosporine moderate
- Amiloride moderate
- Heparin moderate
Frequently Asked Questions
Can I take Indomethacin and Perindopril together?
This is a moderate interaction. Your doctor may need to adjust your doses and will likely order regular blood tests to check your potassium.
How serious is the interaction between Indomethacin and Perindopril?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Indomethacin and Perindopril interact?
Using these medicines at the same time can cause your blood potassium levels to rise too high.
Understanding the Indomethacin and Perindopril Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Indomethacin belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Perindopril belongs to the ACE Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Using these medicines at the same time can cause your blood potassium levels to rise too high. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Indomethacin has 35 total documented interactions on file in this dataset, and Perindopril has 9. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your doses and will likely order regular blood tests to check your potassium. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Indomethacin or Perindopril based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.