What the FDA labels say about taking them together
Indomethacin and perindopril
Perindopril's FDA label of March 13, 2024 names indomethacin in its drug interactions section; indomethacin's label does not name perindopril itself but warns about its class (ACE inhibitors). The perindopril label: “Use of potassium-sparing diuretics, potassium supplements or other drugs capable of increasing serum potassium can increase the risk of hyperkalemia.”
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the perindopril FDA label on DailyMed (effective March 13, 2024, Aurobindo Pharma Limited).
What does the indomethacin label say about perindopril?
Indomethacin's label does not name perindopril itself; it warns about its class (ACE inhibitors):
Indomethacin label, drug interactionsNSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol).
Indomethacin label, drug interactionsNSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol). In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the perindopril label say about indomethacin?
Perindopril label, drug interactionsUse of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Source: FDA drug label (Perindopril Erbumine), Aurobindo Pharma Limited, effective March 13, 2024 (SPL set 87768fbf-7c63-47da-8925-0316f343d6ef), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indomethacin | Perindopril | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | High blood pressure, Heart attack and coronary artery disease |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | $0.495 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once