Indomethacin and Aspirin Interaction
Drug interaction information between Indomethacin and Aspirin.
Indomethacin and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Indomethacin and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these together increases the risk of bleeding because both drugs affect how your blood clots and can irritate your stomach.
FDA Label Information
Intervention: Monitor patients with concomitant use of indomethacin capsules with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding [ see Warnings and Precautions ( 5.12 ) ] . Aspirin Clinical Impact: Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was...
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Indomethacin + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Indomethacin's 35. In the minor band specifically: Indomethacin has 30 (also Meloxicam, Diclofenac, Cyclosporine, Lithium); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Indomethacin and Aspirin?
Taking these together increases the risk of bleeding because both drugs affect how your blood clots and can irritate your stomach.
Aspirin carries more major-labeled pairs than Indomethacin
SPL source-record counts only. This page's band is minor · classes on file: Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Indomethacin's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Diclofenac
- Cyclosporine
- Lithium
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.