What the FDA labels say about taking them together
Aspirin and indomethacin
Indomethacin's FDA label of December 19, 2025 names aspirin in its contraindications section; aspirin's label does not name indomethacin itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The indomethacin label: “• Indomethacin and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of indomethacin and anticoagulants have an increased risk of serious bleeding compared to the use of either …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the aspirin label say about indomethacin?
Aspirin's label does not name indomethacin itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the indomethacin label say about aspirin?
Indomethacin label, contraindicationsHistory of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Indomethacin label, drug interactionsDrugs That Interfere with Hemostasis Clinical Impact: • Indomethacin and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of indomethacin and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. • Serotonin release by platelets plays an important role in hemostasis. … Intervention: Monitor patients with concomitant use of indomethacin capsules with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding [ see Warnings and …
Indomethacin label, warnings and precautionsExacerbation of Asthma Related to Aspirin Sensitivity: Indomethacin capsules are contraindicated in patients with aspirin-sensitive asthma.
Indomethacin label (Chartwell RX, LLC, March 26, 2025), contraindicationsIndomethacin should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Indomethacin label (Chartwell RX, LLC, March 26, 2025), drug interactionsAspirin When indomethacin is administered with aspirin, its protein binding is reduced, although the clearance of free indomethacin is not altered.
Indocin label (Zyla Life Sciences US LLC, December 16, 2024), contraindicationsCONTRAINDICATIONS INDOCIN is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to indomethacin or any components of the drug product [ see Warnings and Precautions ( 5.7 , 5.9 ) ] History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Source: FDA drug label (Indomethacin, NDA018829), Chartwell RX, LLC, effective March 26, 2025 (SPL set 9607920c-4d25-40b9-957e-87e9ca5574e8), via openFDA
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Indomethacin | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.210 per capsule 75 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once