Indomethacin and Warfarin Interaction
Drug interaction information between Indomethacin and Warfarin.
Indomethacin and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Indomethacin and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Indomethacin can irritate the stomach and slow down blood clotting. When combined with warfarin, these effects add up and significantly raise your chance of bleeding.
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Meloxicam minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Indomethacin + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Indomethacin's 35. In the moderate band specifically: Indomethacin has 5 (also Methotrexate, Diflunisal, Heparin, Perindopril); Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Indomethacin and Warfarin?
Indomethacin can irritate the stomach and slow down blood clotting. When combined with warfarin, these effects add up and significantly raise your chance of bleeding.
Warfarin carries more major-labeled pairs than Indomethacin
SPL source-record counts only. This page's band is moderate · classes on file: Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Indomethacin's 0. This page itself is in the moderate band, not the major band.
0 major · 5 moderate · 30 minor · 35 total
- Other moderate peers for Indomethacin
- Methotrexate
- Diflunisal
- Heparin
- Perindopril
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.