indomethacin vs prazosin
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Side-by-side comparison of indomethacin and prazosin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Indocin
Minipress
Indomethacin is a drug that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
Prazosin (Minipress) is a medicine that lowers your blood pressure. Lowering blood pressure helps prevent strokes and heart attacks.
Indomethacin treats moderate to severe rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It can also help with acute painful shoulder (bursitis or tendinitis) and gouty arthritis. This medicine reduces pain and swelling in your joints.
Prazosin is used to treat high blood pressure. Lowering your blood pressure reduces your risk of serious heart problems. It can be used alone or with other blood pressure medicines. Managing high blood pressure should include healthy habits like diet and exercise.
Indomethacin works by blocking substances in the body that cause pain and inflammation. These substances are called prostaglandins. By blocking them, indomethacin helps to reduce swelling, pain, and stiffness.
Prazosin belongs to a class of drugs called alpha-1 blockers. It works by relaxing your blood vessels. This makes it easier for blood to flow through your body, which lowers blood pressure.
- • Headache
- • Dizziness
- • Upset stomach
- • Nausea
- • Dizziness
- • Headache
- • Drowsiness
- • Lack of energy
- • Weakness
- Fatigue 1,102
- Arthralgia 1,002
- Headache 990
- Pain 921
- Nausea 907
- Nausea 361
- Headache 265
- Dizziness 263
- Anxiety 260
- Fatigue 257
Indomethacin may increase your risk of serious heart problems like heart attack or stroke, which can be fatal. This risk may occur early in treatment and may increase with longer use. You should not take this medicine before or after heart bypass surgery (CABG). Indomethacin can also increase your risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. Elderly patients and those with a history of ulcers or GI bleeding are at higher risk.
Prazosin can cause a sudden drop in blood pressure, especially when you first start taking it. This can make you feel dizzy or faint. To avoid this, take your first dose at bedtime. Be careful when standing up quickly.
Using indomethacin during the later stages of pregnancy may harm your unborn baby. Limit use between 20 and 30 weeks of pregnancy, and avoid use after 30 weeks. Talk to your doctor if you are pregnant or plan to become pregnant.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if prazosin will harm your unborn baby. Talk to your doctor about the risks and benefits of taking prazosin while pregnant or breastfeeding.
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How to Read This indomethacin vs prazosin Comparison
indomethacin is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while prazosin sits within the Alpha-1 Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, indomethacin has 4,922 submissions while prazosin has 1,406. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to based on limited clinical data, these drugs do not have a known harmful interaction. they appear to be compatible when taken together.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for indomethacin or prazosin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.