What the FDA labels say about taking them together
Glimepiride and olanzapine
Glimepiride's FDA label of May 12, 2025 names olanzapine in its drug interactions section; the olanzapine labels PlainMeds reads (3) do not name glimepiride. The glimepiride label: “The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors …”
Check it at the source: the glimepiride FDA label on DailyMed (effective May 12, 2025, Micro Labs Limited); the olanzapine FDA label on DailyMed (effective March 5, 2026, Macleods Pharmaceuticals Limited).
What does the glimepiride label say about olanzapine?
Glimepiride label, drug interactionsThe following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid.
Source: FDA drug label (Glimepiride), Micro Labs Limited, effective May 12, 2025 (SPL set 60e9397e-83b9-489e-9683-6f87e458bbaa), via openFDA; the full label on DailyMed
What does the olanzapine label say about glimepiride?
Olanzapine's label (effective March 5, 2026) and its 2 other brand-application labels do not name glimepiride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Olanzapine), Macleods Pharmaceuticals Limited, effective March 5, 2026 (SPL set 8e095987-bdea-42f2-9550-c7155cf07d30), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glimepiride | Olanzapine | |
|---|---|---|
| Labeled for | Type 2 diabetes | Schizophrenia, Bipolar disorder, Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0507 per tablet 4 mg tablet | $0.147 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once