Glimepiride and Olanzapine Interaction
Drug interaction information between Glimepiride and Olanzapine.
Glimepiride and Olanzapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glimepiride and Olanzapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Olanzapine can make glimepiride less effective at lowering blood sugar, which might cause your blood sugar levels to rise.
FDA Label Information
The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid.
Glimepiride Also Interacts With
- Albuterol minor
- Fluoxetine minor
- Clonidine minor
- Fluconazole minor
- Clarithromycin minor
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Omeprazole minor
- Warfarin minor
- Diazepam minor
Frequently Asked Questions
What SPL severity band is on file for Glimepiride + Olanzapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Olanzapine has 26 labeled pairs on file vs Glimepiride's 16. In the minor band specifically: Glimepiride has 16 (also Albuterol, Fluoxetine, Clonidine, Fluconazole); Olanzapine has 24 (also Omeprazole, Warfarin, Diazepam, Carbamazepine).
What mechanism field is on file for Glimepiride and Olanzapine?
Olanzapine can make glimepiride less effective at lowering blood sugar, which might cause your blood sugar levels to rise.
Olanzapine carries more major-labeled pairs than Glimepiride
SPL source-record counts only. This page's band is minor · classes on file: Glimepiride (Sulfonylurea); Olanzapine (Atypical Antipsychotic).
Olanzapine has 1 major-labeled pair vs Glimepiride's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 16 minor · 16 total
- Other minor peers for Glimepiride
- Albuterol
- Fluoxetine
- Clonidine
- Fluconazole
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Omeprazole
- Warfarin
- Diazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.