Glimepiride and Fluoxetine Interaction
Drug interaction information between Glimepiride and Fluoxetine.
Glimepiride and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glimepiride and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can increase the effects of glimepiride, which may cause your blood sugar to drop to dangerously low levels.
FDA Label Information
The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly...
Glimepiride Also Interacts With
- Albuterol minor
- Clonidine minor
- Olanzapine minor
- Fluconazole minor
- Clarithromycin minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Glimepiride + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Glimepiride's 16. In the minor band specifically: Glimepiride has 16 (also Albuterol, Clonidine, Olanzapine, Fluconazole); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Glimepiride and Fluoxetine?
Fluoxetine can increase the effects of glimepiride, which may cause your blood sugar to drop to dangerously low levels.
Fluoxetine carries more major-labeled pairs than Glimepiride
SPL source-record counts only. This page's band is minor · classes on file: Glimepiride (Sulfonylurea); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Glimepiride's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 16 minor · 16 total
- Other minor peers for Glimepiride
- Albuterol
- Clonidine
- Olanzapine
- Fluconazole
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.