What the FDA labels say about taking them together
Clonidine and glimepiride
Glimepiride's FDA label of May 12, 2025 names clonidine in its drug interactions section; the clonidine labels PlainMeds reads (4) do not name glimepiride.
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the glimepiride FDA label on DailyMed (effective May 12, 2025, Micro Labs Limited).
What does the clonidine label say about glimepiride?
Clonidine's label (effective March 30, 2026) and its 3 other brand-application labels do not name glimepiride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the glimepiride label say about clonidine?
Glimepiride label, drug interactionsBeta-blockers, clonidine, and reserpine may lead to either potentiation or weakening of glimepiride’s glucose-lowering effect.
Source: FDA drug label (Glimepiride), Micro Labs Limited, effective May 12, 2025 (SPL set 60e9397e-83b9-489e-9683-6f87e458bbaa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Glimepiride | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $0.0507 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once