Glimepiride and Clonidine Interaction
Drug interaction information between Glimepiride and Clonidine.
Glimepiride and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glimepiride and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clonidine can change how your body responds to blood sugar and may hide the normal warning signs of low blood sugar, like a fast heartbeat.
FDA Label Information
Beta-blockers, clonidine, and reserpine may lead to either potentiation or weakening of glimepiride’s glucose-lowering effect. The signs of hypoglycemia may be reduced or absent in patients taking sympatholytic drugs such as beta-blockers, clonidine, guanethidine, and reserpine.
Glimepiride Also Interacts With
- Albuterol minor
- Fluoxetine minor
- Olanzapine minor
- Fluconazole minor
- Clarithromycin minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Glimepiride + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Glimepiride's 16. In the minor band specifically: Glimepiride has 16 (also Albuterol, Fluoxetine, Olanzapine, Fluconazole); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Glimepiride and Clonidine?
Clonidine can change how your body responds to blood sugar and may hide the normal warning signs of low blood sugar, like a fast heartbeat.
Clonidine's labeled portfolio outnumbers Glimepiride
SPL source-record counts only. This page's band is minor · classes on file: Glimepiride (Sulfonylurea); Clonidine (Central Alpha-2 Agonist).
0 major · 0 moderate · 16 minor · 16 total
- Other minor peers for Glimepiride
- Albuterol
- Fluoxetine
- Olanzapine
- Fluconazole
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.