Glimepiride and Fluconazole Interaction
Drug interaction information between Glimepiride and Fluconazole.
Glimepiride and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glimepiride and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole can increase the effect of glimepiride, which makes it more likely for your blood sugar to drop to a dangerously low level.
FDA Label Information
The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly...
Glimepiride Also Interacts With
- Albuterol minor
- Fluoxetine minor
- Clonidine minor
- Olanzapine minor
- Clarithromycin minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Glimepiride + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Glimepiride's 16. In the minor band specifically: Glimepiride has 16 (also Albuterol, Fluoxetine, Clonidine, Olanzapine); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Glimepiride and Fluconazole?
Fluconazole can increase the effect of glimepiride, which makes it more likely for your blood sugar to drop to a dangerously low level.
Fluconazole carries more major-labeled pairs than Glimepiride
SPL source-record counts only. This page's band is minor · classes on file: Glimepiride (Sulfonylurea); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Glimepiride's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 16 minor · 16 total
- Other minor peers for Glimepiride
- Albuterol
- Fluoxetine
- Clonidine
- Olanzapine
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.