Glimepiride and Albuterol Interaction
Drug interaction information between Glimepiride and Albuterol.
Glimepiride and Albuterol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glimepiride and Albuterol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Albuterol can cause blood sugar levels to rise, which works against the effects of the diabetes medicine glimepiride.
FDA Label Information
The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid.
Glimepiride Also Interacts With
- Fluoxetine minor
- Clonidine minor
- Olanzapine minor
- Fluconazole minor
- Clarithromycin minor
Albuterol Also Interacts With
- Theophylline major
- Albuterol/Ipratropium moderate
- Atomoxetine moderate
- Digoxin minor
- Insulin Aspart minor
Frequently Asked Questions
What SPL severity band is on file for Glimepiride + Albuterol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Glimepiride and Albuterol tie at 16 labeled pairs each. minor-band counts: Glimepiride 16 alongside Fluoxetine, Clonidine, Olanzapine, Fluconazole; Albuterol 13 alongside Digoxin, Insulin Aspart, Insulin Degludec, Insulin Detemir.
What mechanism field is on file for Glimepiride and Albuterol?
Albuterol can cause blood sugar levels to rise, which works against the effects of the diabetes medicine glimepiride.
Albuterol carries more major-labeled pairs than Glimepiride
SPL source-record counts only. This page's band is minor · classes on file: Glimepiride (Sulfonylurea); Albuterol (Short-Acting Beta-2 Agonist).
Albuterol has 1 major-labeled pair vs Glimepiride's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 16 minor · 16 total
- Other minor peers for Glimepiride
- Fluoxetine
- Clonidine
- Olanzapine
- Fluconazole
1 major · 2 moderate · 13 minor · 16 total
- Other minor peers for Albuterol
- Digoxin
- Insulin Aspart
- Insulin Degludec
- Insulin Detemir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.