What the FDA labels say about taking them together
Alprazolam and aprepitant
Aprepitant's FDA label of July 5, 2024 names alprazolam in its drug interactions section; the alprazolam labels PlainMeds reads (2) do not name aprepitant. The aprepitant label: “Clinical Impact; Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions.”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the aprepitant FDA label on DailyMed (effective July 5, 2024, Merck Sharp & Dohme LLC).
What does the alprazolam label say about aprepitant?
Alprazolam's label (effective January 18, 2023) and its 1 other brand-application label do not name aprepitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the aprepitant label say about alprazolam?
Aprepitant label, drug interactionsClinical Impact; Increased exposure to midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) may increase the risk of adverse reactions [see ].
Source: FDA drug label (EMEND), NDA021549 (Msd), as published by Merck Sharp & Dohme LLC, effective July 5, 2024 (SPL set 696f9e80-9cae-403b-de9e-078343ce4713), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Aprepitant | |
|---|---|---|
| Labeled for | Anxiety | Nausea and vomiting |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | $46.42 per capsule 40 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once