Pimozide and Fluconazole Interaction
Drug interaction information between Pimozide and Fluconazole.
Pimozide and Fluconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pimozide and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluconazole slows down how your body breaks down pimozide, which can cause the drug to build up and lead to dangerous heart rhythm problems.
What To Do
This combination is not allowed and should be avoided entirely.
FDA Label Information
(See CLINICAL PHARMACOLOGY: Drug Interaction Studies .) Pimozide : Although not studied in vitro or in vivo , concomitant administration of fluconazole with pimozide may result in inhibition of pimozide metabolism. Increased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsade de pointes. Coadministration of fluconazole and pimozide is contraindicated.
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Fluconazole Also Interacts With
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
- Carbamazepine moderate
Frequently Asked Questions
Can I take Pimozide and Fluconazole together?
This is a major interaction. This combination is not allowed and should be avoided entirely.
How serious is the interaction between Pimozide and Fluconazole?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Pimozide and Fluconazole interact?
Fluconazole slows down how your body breaks down pimozide, which can cause the drug to build up and lead to dangerous heart rhythm problems.
Understanding the Pimozide and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Pimozide belongs to the Typical Antipsychotic class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluconazole slows down how your body breaks down pimozide, which can cause the drug to build up and lead to dangerous heart rhythm problems. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Pimozide has 24 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: This combination is not allowed and should be avoided entirely. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Pimozide or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.