Pimozide and Fluconazole Interaction
Drug interaction information between Pimozide and Fluconazole.
Pimozide and Fluconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Pimozide and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole slows down how your body breaks down pimozide, which can cause the drug to build up and lead to dangerous heart rhythm problems.
FDA Label Information
(See CLINICAL PHARMACOLOGY: Drug Interaction Studies .) Pimozide : Although not studied in vitro or in vivo , concomitant administration of fluconazole with pimozide may result in inhibition of pimozide metabolism. Increased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsade de pointes. Coadministration of fluconazole and pimozide is contraindicated.
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Fluconazole Also Interacts With
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
- Carbamazepine moderate
Frequently Asked Questions
What SPL severity band is on file for Pimozide + Fluconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Pimozide's 24. In the major band specifically: Pimozide has 12 (also Aprepitant, Citalopram, Clarithromycin, Darunavir); Fluconazole has 3 (also Clarithromycin, Eplerenone).
What mechanism field is on file for Pimozide and Fluconazole?
Fluconazole slows down how your body breaks down pimozide, which can cause the drug to build up and lead to dangerous heart rhythm problems.
Pimozide carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is major · classes on file: Pimozide (Typical Antipsychotic); Fluconazole (Azole Antifungal).
Pimozide has 12 major-labeled pairs vs Fluconazole's 3.
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Citalopram
- Clarithromycin
- Darunavir
3 major · 7 moderate · 57 minor · 67 total
- Other major peers for Fluconazole
- Clarithromycin
- Eplerenone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.