What the FDA labels say about taking them together
Aprepitant and ketoconazole
Aprepitant's FDA label of July 5, 2024 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name aprepitant. The aprepitant label: “Use of EMEND with strong or moderate CYP3A4 inhibitors may increase plasma concentrations of aprepitant and result in an increased risk of adverse reactions related to EMEND.”
Check it at the source: the aprepitant FDA label on DailyMed (effective July 5, 2024, Merck Sharp & Dohme LLC); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the aprepitant label say about ketoconazole?
Aprepitant label, drug interactionsExamples; Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir
Aprepitant label, warnings and precautionsUse of EMEND with strong or moderate CYP3A4 inhibitors (e.g., ketoconazole, diltiazem) may increase plasma concentrations of aprepitant and result in an increased risk of adverse reactions related to EMEND.
Source: FDA drug label (Cinvanti, NDA209296), Heron Therapeutics, Inc., effective April 1, 2026 (SPL set 4c218d3a-a508-4abc-9ed8-a6e8e191d1b4), via openFDA
Source: FDA drug label (Aponvie, NDA216457), Heron Therapeutics, Inc., effective April 1, 2026 (SPL set d1b111eb-659a-496b-a86a-8f0fa370f147), via openFDA
Source: FDA drug label (EMEND), NDA021549 (Msd), as published by Merck Sharp & Dohme LLC, effective July 5, 2024 (SPL set 696f9e80-9cae-403b-de9e-078343ce4713), via openFDA; the full label on DailyMed
What does the ketoconazole label say about aprepitant?
Ketoconazole's label (effective January 28, 2026) does not name aprepitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aprepitant | Ketoconazole | |
|---|---|---|
| Labeled for | Nausea and vomiting | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $46.42 per capsule 40 mg capsule | $0.249 per gram 2% cream |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once