Aprepitant and Diltiazem Interaction
Drug interaction information between Aprepitant and Diltiazem.
Aprepitant and Diltiazem have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aprepitant and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem slows down the body's ability to process aprepitant, which can increase the amount of aprepitant in your blood.
FDA Label Information
Intervention Avoid concomitant use of aprepitant Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir Strong CYP3A4 Inducers Clinical Impact Substantially decreased exposure of aprepitant in patients chronically taking a strong CYP3A4 inducer may decrease the efficacy of aprepitant [see Clinical Pharmacology ( 12.3 )] . Intervention Avoid concomitant use of aprepitant Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin,...
Aprepitant Also Interacts With
- Pimozide major
- Alprazolam moderate
- Methylprednisolone moderate
- Ketoconazole moderate
- Clarithromycin moderate
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Aprepitant + Diltiazem?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Aprepitant's 22. In the moderate band specifically: Aprepitant has 9 (also Alprazolam, Methylprednisolone, Ketoconazole, Clarithromycin); Diltiazem has 7 (also Rifampin, Digoxin, Ivabradine, Metoprolol).
What mechanism field is on file for Aprepitant and Diltiazem?
Diltiazem slows down the body's ability to process aprepitant, which can increase the amount of aprepitant in your blood.
Diltiazem carries more major-labeled pairs than Aprepitant
SPL source-record counts only. This page's band is moderate · classes on file: Aprepitant (NK1 Receptor Antagonist (Antiemetic)); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Aprepitant's 1. This page itself is in the moderate band, not the major band.
1 major · 9 moderate · 12 minor · 22 total
- Other moderate peers for Aprepitant
- Alprazolam
- Methylprednisolone
- Ketoconazole
- Clarithromycin
4 major · 7 moderate · 35 minor · 46 total
- Other moderate peers for Diltiazem
- Rifampin
- Digoxin
- Ivabradine
- Metoprolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.