What the FDA labels say about taking them together
Aprepitant and methylprednisolone
Aprepitant's FDA label of July 5, 2024 names methylprednisolone in its drug interactions section; the methylprednisolone labels PlainMeds reads (3) do not name aprepitant. The aprepitant label: “Clinical Impact; Increased methylprednisolone exposure.”
Check it at the source: the aprepitant FDA label on DailyMed (effective July 5, 2024, Merck Sharp & Dohme LLC); the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.).
What does the aprepitant label say about methylprednisolone?
Aprepitant label, drug interactionsMethylprednisolone Clinical Impact Increased methylprednisolone exposure [see Clinical Pharmacology (12.3) ].
Cinvanti label (Heron Therapeutics, Inc., April 1, 2026), drug interactionsClinical Impact; Increased methylprednisolone exposure [see ].
Aponvie label (Heron Therapeutics, Inc., April 1, 2026), drug interactionsClinical Impact; No clinically significant change in the exposure of dexamethasone or methylprednisolone [see ].
Source: FDA drug label (Cinvanti, NDA209296), Heron Therapeutics, Inc., effective April 1, 2026 (SPL set 4c218d3a-a508-4abc-9ed8-a6e8e191d1b4), via openFDA
Source: FDA drug label (Aponvie, NDA216457), Heron Therapeutics, Inc., effective April 1, 2026 (SPL set d1b111eb-659a-496b-a86a-8f0fa370f147), via openFDA
Source: FDA drug label (EMEND), NDA021549 (Msd), as published by Merck Sharp & Dohme LLC, effective July 5, 2024 (SPL set 696f9e80-9cae-403b-de9e-078343ce4713), via openFDA; the full label on DailyMed
What does the methylprednisolone label say about aprepitant?
Methylprednisolone's label (effective June 22, 2026) and its 2 other brand-application labels do not name aprepitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aprepitant | Methylprednisolone | |
|---|---|---|
| Labeled for | Nausea and vomiting | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $46.42 per capsule 40 mg capsule | $0.121 per tablet 4 mg tablet |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once