Aprepitant and Clarithromycin Interaction
Drug interaction information between Aprepitant and Clarithromycin.
Aprepitant and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aprepitant and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin is a strong inhibitor that stops your body from breaking down aprepitant, which can lead to higher drug levels.
FDA Label Information
Intervention Avoid concomitant use of aprepitant Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir Strong CYP3A4 Inducers Clinical Impact Substantially decreased exposure of aprepitant in patients chronically taking a strong CYP3A4 inducer may decrease the efficacy of aprepitant [see Clinical Pharmacology ( 12.3 )] . Intervention Avoid concomitant use of aprepitant Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin,...
Aprepitant Also Interacts With
- Pimozide major
- Alprazolam moderate
- Diltiazem moderate
- Methylprednisolone moderate
- Ketoconazole moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Aprepitant + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Aprepitant's 22. In the moderate band specifically: Aprepitant has 9 (also Alprazolam, Diltiazem, Methylprednisolone, Ketoconazole); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Aprepitant and Clarithromycin?
Clarithromycin is a strong inhibitor that stops your body from breaking down aprepitant, which can lead to higher drug levels.
Clarithromycin carries more major-labeled pairs than Aprepitant
SPL source-record counts only. This page's band is moderate · classes on file: Aprepitant (NK1 Receptor Antagonist (Antiemetic)); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Aprepitant's 1. This page itself is in the moderate band, not the major band.
1 major · 9 moderate · 12 minor · 22 total
- Other moderate peers for Aprepitant
- Alprazolam
- Diltiazem
- Methylprednisolone
- Ketoconazole
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.