Buprenorphine and Cyclobenzaprine Interaction
Drug interaction information between Buprenorphine and Cyclobenzaprine.
Buprenorphine and Cyclobenzaprine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buprenorphine and Cyclobenzaprine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This muscle relaxant and the pain medication both raise serotonin levels. Using them at the same time can cause a toxic reaction in your nervous system.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy of...
Buprenorphine Also Interacts With
- Gabapentin minor
- Trazodone minor
- Tramadol minor
- Pregabalin minor
- Mirtazapine minor
Cyclobenzaprine Also Interacts With
- Clozapine moderate
- Tapentadol moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine minor
Frequently Asked Questions
What SPL severity band is on file for Buprenorphine (Pain) + Cyclobenzaprine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buprenorphine has 19 labeled pairs on file vs Cyclobenzaprine's 17. In the minor band specifically: Buprenorphine has 19 (also Gabapentin, Trazodone, Tramadol, Pregabalin); Cyclobenzaprine has 14 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Codeine).
What mechanism field is on file for Buprenorphine (Pain) and Cyclobenzaprine?
This muscle relaxant and the pain medication both raise serotonin levels. Using them at the same time can cause a toxic reaction in your nervous system.
Buprenorphine's labeled portfolio outnumbers Cyclobenzaprine
SPL source-record counts only. This page's band is minor · classes on file: Buprenorphine (Partial Opioid Agonist); Cyclobenzaprine (Muscle Relaxant).
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine
- Gabapentin
- Trazodone
- Tramadol
- Pregabalin
0 major · 3 moderate · 14 minor · 17 total
- Other minor peers for Cyclobenzaprine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.