Buprenorphine and Pregabalin Interaction
Drug interaction information between Buprenorphine and Pregabalin.
Buprenorphine and Pregabalin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buprenorphine and Pregabalin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs slow down your brain activity and breathing. Taking them together can make you very sleepy or make it hard to breathe.
FDA Label Information
Examples: Benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin),, other opioids, alcohol.
Buprenorphine Also Interacts With
- Gabapentin minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
Pregabalin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Lamotrigine minor
- Topiramate minor
- Lorazepam minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Buprenorphine (Pain) + Pregabalin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buprenorphine has 19 labeled pairs on file vs Pregabalin's 14. In the minor band specifically: Buprenorphine has 19 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine); Pregabalin has 13 (also Lamotrigine, Topiramate, Lorazepam, Carbamazepine).
What mechanism field is on file for Buprenorphine (Pain) and Pregabalin?
Both of these drugs slow down your brain activity and breathing. Taking them together can make you very sleepy or make it hard to breathe.
Buprenorphine's labeled portfolio outnumbers Pregabalin
SPL source-record counts only. This page's band is minor · classes on file: Buprenorphine (Partial Opioid Agonist); Pregabalin (Anticonvulsant / Nerve Pain Agent).
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Pregabalin
- Lamotrigine
- Topiramate
- Lorazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.