Buprenorphine/Naloxone and Gabapentin Interaction
Drug interaction information between Buprenorphine/Naloxone and Gabapentin.
Buprenorphine/Naloxone and Gabapentin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buprenorphine/Naloxone and Gabapentin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines are both sedatives that can slow down your breathing and brain activity. Using them together makes these side effects much stronger and more dangerous.
FDA Label Information
Examples: Alcohol, benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), and other opioids.
Buprenorphine/Naloxone Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Pregabalin minor
- Mirtazapine minor
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
Frequently Asked Questions
What SPL severity band is on file for Buprenorphine/Naloxone + Gabapentin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Buprenorphine/Naloxone and Gabapentin tie at 19 labeled pairs each. minor-band counts: Buprenorphine/Naloxone 19 alongside Trazodone, Tramadol, Cyclobenzaprine, Pregabalin; Gabapentin 18 alongside Oxycodone, Estradiol, Naproxen, Norethindrone.
What mechanism field is on file for Buprenorphine/Naloxone and Gabapentin?
These medicines are both sedatives that can slow down your breathing and brain activity. Using them together makes these side effects much stronger and more dangerous.
Buprenorphine/Naloxone and Gabapentin · minor-band peers
SPL source-record counts only. This page's band is minor · classes on file: Buprenorphine/Naloxone (Partial Opioid Agonist / Antagonist); Gabapentin (Anticonvulsant / Nerve Pain Agent).
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine/Naloxone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Oxycodone
- Estradiol
- Naproxen
- Norethindrone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.