Buprenorphine/Naloxone and Pregabalin Interaction
Drug interaction information between Buprenorphine/Naloxone and Pregabalin.
Buprenorphine/Naloxone and Pregabalin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buprenorphine/Naloxone and Pregabalin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both slow down your brain and breathing, which can make you very sleepy or cause dangerous breathing issues.
FDA Label Information
Examples: Alcohol, benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), and other opioids.
Buprenorphine/Naloxone Also Interacts With
- Gabapentin minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
Pregabalin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Lamotrigine minor
- Topiramate minor
- Lorazepam minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Buprenorphine/Naloxone + Pregabalin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buprenorphine/Naloxone has 19 labeled pairs on file vs Pregabalin's 14. In the minor band specifically: Buprenorphine/Naloxone has 19 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine); Pregabalin has 13 (also Lamotrigine, Topiramate, Lorazepam, Carbamazepine).
What mechanism field is on file for Buprenorphine/Naloxone and Pregabalin?
These drugs both slow down your brain and breathing, which can make you very sleepy or cause dangerous breathing issues.
Buprenorphine/Naloxone's labeled portfolio outnumbers Pregabalin
SPL source-record counts only. This page's band is minor · classes on file: Buprenorphine/Naloxone (Partial Opioid Agonist / Antagonist); Pregabalin (Anticonvulsant / Nerve Pain Agent).
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine/Naloxone
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Pregabalin
- Lamotrigine
- Topiramate
- Lorazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.