Buprenorphine and Mirtazapine Interaction
Drug interaction information between Buprenorphine and Mirtazapine.
Buprenorphine and Mirtazapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buprenorphine and Mirtazapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both affect the serotonin system, and taking them together can lead to a dangerous buildup of this chemical in your body.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Buprenorphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Cyclobenzaprine minor
- Ketoconazole minor
- Carbamazepine minor
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Buprenorphine + Mirtazapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Buprenorphine and Mirtazapine tie at 29 labeled pairs each. minor-band counts: Buprenorphine 28 alongside Trazodone, Cyclobenzaprine, Ketoconazole, Carbamazepine; Mirtazapine 23 alongside Buspirone, Warfarin, Carbamazepine, Lithium.
What mechanism field is on file for Buprenorphine and Mirtazapine?
These medications both affect the serotonin system, and taking them together can lead to a dangerous buildup of this chemical in your body.
Mirtazapine carries more major-labeled pairs than Buprenorphine
SPL source-record counts only. This page's band is minor · classes on file: Buprenorphine (Partial Opioid Agonist); Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)).
Mirtazapine has 1 major-labeled pair vs Buprenorphine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 28 minor · 29 total
- Other minor peers for Buprenorphine
- Trazodone
- Cyclobenzaprine
- Ketoconazole
- Carbamazepine
1 major · 5 moderate · 23 minor · 29 total
- Other minor peers for Mirtazapine
- Buspirone
- Warfarin
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.