Buprenorphine and Cyclobenzaprine Interaction
Drug interaction information between Buprenorphine and Cyclobenzaprine.
Buprenorphine and Cyclobenzaprine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buprenorphine and Cyclobenzaprine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase serotonin levels in the brain, which can cause a serious and potentially dangerous reaction.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Buprenorphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Mirtazapine minor
- Ketoconazole minor
- Carbamazepine minor
Cyclobenzaprine Also Interacts With
- Clozapine moderate
- Tapentadol moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine/Naloxone minor
Frequently Asked Questions
What SPL severity band is on file for Buprenorphine + Cyclobenzaprine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buprenorphine has 29 labeled pairs on file vs Cyclobenzaprine's 17. In the minor band specifically: Buprenorphine has 28 (also Trazodone, Mirtazapine, Ketoconazole, Carbamazepine); Cyclobenzaprine has 14 (also Acetaminophen/Oxycodone, Buprenorphine/Naloxone, Buprenorphine, Codeine).
What mechanism field is on file for Buprenorphine and Cyclobenzaprine?
Both drugs increase serotonin levels in the brain, which can cause a serious and potentially dangerous reaction.
Buprenorphine's labeled portfolio outnumbers Cyclobenzaprine
SPL source-record counts only. This page's band is minor · classes on file: Buprenorphine (Partial Opioid Agonist); Cyclobenzaprine (Muscle Relaxant).
0 major · 1 moderate · 28 minor · 29 total
- Other minor peers for Buprenorphine
- Trazodone
- Mirtazapine
- Ketoconazole
- Carbamazepine
0 major · 3 moderate · 14 minor · 17 total
- Other minor peers for Cyclobenzaprine
- Acetaminophen/Oxycodone
- Buprenorphine/Naloxone
- Buprenorphine
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.