Oxybutynin and Carbamazepine Interaction
Drug interaction information between Oxybutynin and Carbamazepine.
Oxybutynin and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxybutynin and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Oxybutynin can increase the amount of carbamazepine in your blood by slowing down its removal from your body.
FDA Label Information
Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors.
Oxybutynin Also Interacts With
- Ketoconazole minor
- Erythromycin minor
- Clarithromycin minor
- Itraconazole minor
- Metoclopramide minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Oxybutynin + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Oxybutynin's 7. In the minor band specifically: Oxybutynin has 7 (also Ketoconazole, Erythromycin, Clarithromycin, Itraconazole); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Oxybutynin and Carbamazepine?
Oxybutynin can increase the amount of carbamazepine in your blood by slowing down its removal from your body.
Carbamazepine carries more major-labeled pairs than Oxybutynin
SPL source-record counts only. This page's band is minor · classes on file: Oxybutynin (Anticholinergic / Antispasmodic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Oxybutynin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Oxybutynin
- Ketoconazole
- Erythromycin
- Clarithromycin
- Itraconazole
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.