Oxybutynin and Clarithromycin Interaction
Drug interaction information between Oxybutynin and Clarithromycin.
Oxybutynin and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxybutynin and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the natural enzymes that break down oxybutynin in your system. This leads to more of the drug staying in your body for a longer time.
FDA Label Information
Other inhibitors of the cytochrome P450 3A4 enzyme system, such as antimycotic agents (e.g., itraconazole and miconazole) or macrolide antibiotics (e.g., erythromycin and clarithromycin), may alter oxybutynin mean pharmacokinetic parameters (i.e., C max and AUC).
Oxybutynin Also Interacts With
- Ketoconazole minor
- Erythromycin minor
- Itraconazole minor
- Metoclopramide minor
- Carbamazepine minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Oxybutynin + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Oxybutynin's 7. In the minor band specifically: Oxybutynin has 7 (also Ketoconazole, Erythromycin, Itraconazole, Metoclopramide); Clarithromycin has 30 (also Amlodipine, Lorazepam, Diltiazem, Erythromycin).
What mechanism field is on file for Oxybutynin and Clarithromycin?
Clarithromycin blocks the natural enzymes that break down oxybutynin in your system. This leads to more of the drug staying in your body for a longer time.
Clarithromycin carries more major-labeled pairs than Oxybutynin
SPL source-record counts only. This page's band is minor · classes on file: Oxybutynin (Anticholinergic / Antispasmodic); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Oxybutynin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Oxybutynin
- Ketoconazole
- Erythromycin
- Itraconazole
- Metoclopramide
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Diltiazem
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.