Oxybutynin and Itraconazole Interaction
Drug interaction information between Oxybutynin and Itraconazole.
Oxybutynin and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxybutynin and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole interferes with how your body processes oxybutynin. This can increase the amount of oxybutynin in your bloodstream.
FDA Label Information
Other inhibitors of the cytochrome P450 3A4 enzyme system, such as antimycotic agents (e.g., itraconazole and miconazole) or macrolide antibiotics (e.g., erythromycin and clarithromycin), may alter oxybutynin mean pharmacokinetic parameters (i.e., C max and AUC).
Oxybutynin Also Interacts With
- Ketoconazole minor
- Erythromycin minor
- Clarithromycin minor
- Metoclopramide minor
- Carbamazepine minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Oxybutynin + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Oxybutynin's 7. In the minor band specifically: Oxybutynin has 7 (also Ketoconazole, Erythromycin, Clarithromycin, Metoclopramide); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Oxybutynin and Itraconazole?
Itraconazole interferes with how your body processes oxybutynin. This can increase the amount of oxybutynin in your bloodstream.
Itraconazole carries more major-labeled pairs than Oxybutynin
SPL source-record counts only. This page's band is minor · classes on file: Oxybutynin (Anticholinergic / Antispasmodic); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Oxybutynin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Oxybutynin
- Ketoconazole
- Erythromycin
- Clarithromycin
- Metoclopramide
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.