What the FDA labels say about taking them together
Itraconazole and oxybutynin
Itraconazole's FDA label of July 13, 2026 names oxybutynin in its drug interactions section, and oxybutynin's label names itraconazole too. The itraconazole label: “Dutasteride Oxybutynin Sildenafil (for erectile dysfunction) Tadalafil Tolterodine Monitor for adverse reactions.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the oxybutynin FDA label on DailyMed (effective December 16, 2025, Accord Healthcare, Inc.).
What does the itraconazole label say about oxybutynin?
Itraconazole label, drug interactionsDutasteride Oxybutynin Sildenafil (for erectile dysfunction) Tadalafil (for erectile dysfunction and benign prostatic hyperplasia) Tolterodine Monitor for adverse reactions.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the oxybutynin label say about itraconazole?
Oxybutynin label, drug interactionsOther inhibitors of the cytochrome P450 3A4 enzyme system, such as antimycotic agents (e.g., itraconazole and miconazole) or macrolide antibiotics (e.g., erythromycin and clarithromycin), may alter oxybutynin mean pharmacokinetic parameters (i.e., C max and AUC).
Oxytrol label (Allergan, Inc., May 29, 2024), drug interactionsPharmacokinetic studies have not been performed with patients concomitantly receiving cytochrome P450 enzyme inhibitors, such as antimycotic agents (e.g., ketoconazole, itraconazole, and miconazole) or macrolide antibiotics (e.g., erythromycin and clarithromycin).
Source: FDA drug label (Oxytrol, NDA021351), Allergan, Inc., effective May 29, 2024 (SPL set 20dee37f-1412-44ed-9e8b-f4379ce23eb0), via openFDA
Source: FDA drug label (oxybutynin chloride), Accord Healthcare, Inc., effective December 16, 2025 (SPL set 61496a1e-17bf-4f45-a20c-5bb98fe545ee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Oxybutynin | |
|---|---|---|
| Labeled for | Fungal infections | Overactive bladder |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.048 per tablet 5 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once