Oxybutynin and Metoclopramide Interaction
Drug interaction information between Oxybutynin and Metoclopramide.
Oxybutynin and Metoclopramide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxybutynin and Metoclopramide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs have opposite effects on how your digestive system moves. Oxybutynin can block metoclopramide from doing its job of moving food through your stomach.
FDA Label Information
Anticholinergic agents may also antagonize the effects of prokinetic agents, such as metoclopramide.
Oxybutynin Also Interacts With
- Ketoconazole minor
- Erythromycin minor
- Clarithromycin minor
- Itraconazole minor
- Carbamazepine minor
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Oxybutynin + Metoclopramide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Oxybutynin's 7. In the minor band specifically: Oxybutynin has 7 (also Ketoconazole, Erythromycin, Clarithromycin, Itraconazole); Metoclopramide has 18 (also Acetaminophen, Cyclosporine, Tetracycline, Atovaquone/Proguanil).
What mechanism field is on file for Oxybutynin and Metoclopramide?
These two drugs have opposite effects on how your digestive system moves. Oxybutynin can block metoclopramide from doing its job of moving food through your stomach.
Metoclopramide carries more major-labeled pairs than Oxybutynin
SPL source-record counts only. This page's band is minor · classes on file: Oxybutynin (Anticholinergic / Antispasmodic); Metoclopramide (Prokinetic / Antiemetic).
Metoclopramide has 1 major-labeled pair vs Oxybutynin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Oxybutynin
- Ketoconazole
- Erythromycin
- Clarithromycin
- Itraconazole
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Acetaminophen
- Cyclosporine
- Tetracycline
- Atovaquone/Proguanil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.