Aripiprazole and Escitalopram Interaction
Drug interaction information between Aripiprazole and Escitalopram.
Aripiprazole and Escitalopram have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aripiprazole and Escitalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aripiprazole does not affect the levels of escitalopram in your body.
FDA Label Information
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Fluoxetine minor
- Famotidine minor
- Venlafaxine minor
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Aspirin moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Aripiprazole + Escitalopram?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aripiprazole has 19 labeled pairs on file vs Escitalopram's 12. In the minor band specifically: Aripiprazole has 19 (also Omeprazole, Sertraline, Fluoxetine, Famotidine); Escitalopram has 7 (also Buspirone, Sumatriptan, Carbamazepine, Lithium).
What mechanism field is on file for Aripiprazole and Escitalopram?
Aripiprazole does not affect the levels of escitalopram in your body.
Escitalopram carries more major-labeled pairs than Aripiprazole
SPL source-record counts only. This page's band is minor · classes on file: Aripiprazole (Atypical Antipsychotic); Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
Escitalopram has 3 major-labeled pairs vs Aripiprazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Sertraline
- Fluoxetine
- Famotidine
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Escitalopram
- Buspirone
- Sumatriptan
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.