Aripiprazole and Fluoxetine Interaction
Drug interaction information between Aripiprazole and Fluoxetine.
Aripiprazole and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aripiprazole and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine blocks the enzymes that break down aripiprazole, which can cause the drug to build up to higher levels in your body.
FDA Label Information
7 DRUG INTERACTIONS Dosage adjustment due to drug interactions (7.1): Factors Dosage Adjustments for Aripiprazole Known CYP2D6 Poor Metabolizers Administer half of usual dose Known CYP2D6 Poor Metabolizers and strong CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP2D6 or CYP3A4 inhibitors Administer half of usual dose Strong CYP2D6 and CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP3A4 inducers Double usual dose over 1 to 2 weeks 7.1 Drugs Having Clinically Important Interactions with Aripiprazole Table 25: Clinically Important Drug Interactions with...
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Famotidine minor
- Venlafaxine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Aripiprazole + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Aripiprazole's 19. In the minor band specifically: Aripiprazole has 19 (also Omeprazole, Sertraline, Escitalopram, Famotidine); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Aripiprazole and Fluoxetine?
Fluoxetine blocks the enzymes that break down aripiprazole, which can cause the drug to build up to higher levels in your body.
Fluoxetine carries more major-labeled pairs than Aripiprazole
SPL source-record counts only. This page's band is minor · classes on file: Aripiprazole (Atypical Antipsychotic); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Aripiprazole's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Sertraline
- Escitalopram
- Famotidine
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.