Aripiprazole and Venlafaxine Interaction
Drug interaction information between Aripiprazole and Venlafaxine.
Aripiprazole and Venlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aripiprazole and Venlafaxine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Aripiprazole does not interfere with the liver enzymes that break down venlafaxine.
What To Do
You can continue your current dose of venlafaxine while taking aripiprazole.
FDA Label Information
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Alprazolam minor
Frequently Asked Questions
Can I take Aripiprazole and Venlafaxine together?
This is a minor interaction. You can continue your current dose of venlafaxine while taking aripiprazole.
How serious is the interaction between Aripiprazole and Venlafaxine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Aripiprazole and Venlafaxine interact?
Aripiprazole does not interfere with the liver enzymes that break down venlafaxine.
Understanding the Aripiprazole and Venlafaxine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Aripiprazole belongs to the Atypical Antipsychotic class and Venlafaxine belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Aripiprazole does not interfere with the liver enzymes that break down venlafaxine. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Aripiprazole has 19 total documented interactions on file in this dataset, and Venlafaxine has 22. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can continue your current dose of venlafaxine while taking aripiprazole. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Aripiprazole or Venlafaxine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.