Aripiprazole and Venlafaxine Interaction
Drug interaction information between Aripiprazole and Venlafaxine.
Aripiprazole and Venlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Aripiprazole and Venlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aripiprazole does not interfere with the liver enzymes that break down venlafaxine.
FDA Label Information
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Alprazolam minor
Frequently Asked Questions
What SPL severity band is on file for Aripiprazole + Venlafaxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Venlafaxine has 22 labeled pairs on file vs Aripiprazole's 19. In the minor band specifically: Aripiprazole has 19 (also Omeprazole, Sertraline, Escitalopram, Fluoxetine); Venlafaxine has 20 (also Metoprolol, Fluoxetine, Alprazolam, Warfarin).
What mechanism field is on file for Aripiprazole and Venlafaxine?
Aripiprazole does not interfere with the liver enzymes that break down venlafaxine.
Venlafaxine's labeled portfolio outnumbers Aripiprazole
SPL source-record counts only. This page's band is minor · classes on file: Aripiprazole (Atypical Antipsychotic); Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Sertraline
- Escitalopram
- Fluoxetine
0 major · 2 moderate · 20 minor · 22 total
- Other minor peers for Venlafaxine
- Metoprolol
- Fluoxetine
- Alprazolam
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.